On June 28, 1945, the Monterrey Football Club was officially created, after the drafting of its articles of incorporation.

A day earlier, on June 27, the first shareholders of the team (Paul C. Probert, José Fidalgo, Daniel Mir, Ramón Cárdenas Coronado, Rogelio Cantú, Miguel Talavera and Miguel Galán) had gone to a notary public to formally register the team.

The first board was headed by Enrique Ayala Medina as chairman, Paul C. Probert as vice president, Angel F. Escobedo as secretary and Ramón Cárdenas Coronado as treasurer. 

During the first season of its history, the team had its practice session on a military field court and play at Parque Cuauhtémoc, a baseball field loaned by Cerveceria Cuauhtémoc.

Monterrey made its official debut on the morning of Sunday, August 19, 1945, at Parque Cuauhtémoc with a 1-0 victory over Club San Sebastián, from Leon, thanks to a goal scored by the Spanish-Argentine Jose "Che" Gómez.

The first technical director was Manuel Galán and the first lineup was as follows: Raymundo Palomino; Antenor Medina, Enrique Lizano and Miguel Quezada; Santiago Bonilla, Gonzalo Buenabad, Guillermo "Cuadros" Vidal; Jose "Che" Gómez, Octavio "Gene" Rivera, Leonardo "Chanclas" Zamudio and Arnulfo Avilán.

In its first year, the Club faced a lack of financial support, sponsorships and adequate infrastructure in a city where baseball was the most popular sport. 

On the night of September 14, 1945, the greatest tragedy in the Club’s history occurred: the bus in which the team was traveling to Guadalajara caught fire while refueling in San Juan de los Lagos, Jalisco.

Most of the players were sleeping and were caught in the flames. Some had to be hospitalized due to severe burns. Two of them, Guillermo “Cuadros” Vidal and Costa Rican Enrique Lizano, died weeks later and several had serious injuries that prevented them from continuing to play professional soccer.

The blow was devastating and the team was close to abandoning the tournament, but other clubs helped loaning players. Enrique Escalada, Manuel Pando and Ignacio Trelles, among others, joined the team.

Despite the complicated tournament, the Argentine Emilio Baldonedo shone by scoring 19 goals in 19 games played.

With a remarkable effort, Monterrey finished the season, albeit in last place.  At that time, neither relegation nor the Second Division existed, and Monterrey began its preparation for the 1946-1947 season. 

The board, led at the time by Ramón Cárdenas Coronado, failed to obtain sponsors and decided to request the club’s temporary withdrawal. 

Although this first season was bittersweet, it left an important legacy in the history of the Club and Nuevo Leon: to have initiated soccer in the state.

Soon, new directors and players would emerge to take up the legacy of the Club.